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Continuous flow technique
Continuous Flow Technology
● Continuous flow reaction technology has the advantages of high mass and heat transfer efficiency, intrinsically safe, good process repeatability, small amplification effect and continuous automatic operation，Enables "hazardous processes" to operate in a safe and efficient controlled mode，Protect safety and reduce pollution from the source of the process，It is a globally recognized green path for drug development and production.
● Jiuzhou Pharmaceutical continuous flow technology has the ability of efficient continuous flow process screening and equipment development and application。Practical, flexible and scalable continuous reaction modular technology platform, through module combination and automatic control, can achieve the full continuous production needs of different drugs;
● Reaction types include nitrification reaction, ozonation reaction, Hoffmann degradation reaction, Grignell reaction, oxidation reaction, low temperature reaction (-50℃), high temperature reaction (200℃), Curtius rearrangement, catalytic hydrogenation reaction, photochemical reaction, reaction involving high-energy compounds (such as azide, ethyl diazoacetate, etc.);
● At present, Jiuzhou Pharmaceutical continuous flow reaction technology platform has completed the continuous flow process development of a number of innovative API projects, and achieved commercial scale-up production。
Technical service
● Continuous flow process evaluation
● Rapid screening of continuous flow process conditions
● Continuous flow process commercialization seamless amplification
● Continuous flow commercial equipment design applications
● Continuous flow process transfer
Continuous flow technology platform pilot main equipment
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Applicable reaction types: 1.硝化 2.氧化 3.Grignard reaction 4.Curtius rearrangement reaction 5.Low temperature lithium reagent reaction 6.Gas-liquid and liquid-liquid heterogeneous reactions ..... |
Applicable reaction types: 1.Light triggers free radical reactions 2.Light rearrangement reaction 3.Photocyclization reaction ..... |
Applicable reaction types: 1.Nitro-reduction reaction 2.N-, O- debenzylation reaction 3.Ester group reduction reaction 4.dehalogenation 5.Reduction reaction of nitrile compounds 6.Imide reduction reaction 7.Reduction of alkenes and alkynes 8.The carbonylation reaction ..... |
Applicable reaction types: 1.Continuous liquid-solid phase reaction 2.The reaction system is viscous 3.The reaction process produces a solid ... |
Production equipment
