Drug separation technique

Drug Separation Technology

Jiuzhou Pharmaceutical drug separation technology platform can greatly improve research and development and production efficiency。

The drug separation technology platform has a variety of separation and purification capabilities, including normal phase liquid preparation capability, reverse phase liquid preparation capability, ion exchange separation capability, membrane filtration capability and supercritical fluid liquid preparation capability，In the drug development and production process can be eliminated a lot of synthesis process optimization work，Greatly improve work efficiency and ability to respond to project needs。At the same time, using a single mechanism purification method, there are problems of low purification efficiency and large amount of waste liquid。Jiuzhou Pharmaceutical has developed two or more purification preparation methods for purification technology (including membrane filtration, ion exchange, supercritical separation and other technologies)。In particular, it has independent innovative technology for easy gelatinization, insolubility, separation of large polar compounds, small polar compounds, and separation of compounds without ultraviolet absorption (CAD), which can solve such problems well。The drug separation technology platform has a single batch production capacity from mg to kg。

Application of drug separation technology platform

●  In terms of small molecule drugs: this platform has completed the separation and production of dozens of small molecule drugs (molecular weight less than 1000), and completed the preparation and separation of more than 10 kilograms。

●  Macromolecular drugs: Completed the separation of dozens of polypeptide compounds (molecular weight 1000-15000)。

●  More than ten compounds with molecular weight greater than 140,000 were separated and the purity reached 98.5%以上。

●  Completed the delivery of a number of UV-free projects, reaching the 100g level。

●  Six chiral compounds were isolated, and the average ee reached 99.More than 5, on time, quality and quantity delivery to customers。

Platform instrument