Polypeptide technique

Peptide Technology

Jiuzhou Pharmaceutical peptide technology platform has one-stop service capabilities from customized peptides to registration and application, as well as the production of peptide drugs under regulatory conditions。

The peptide technology platform has a strong ability to synthesize peptides, including solid phase synthesis, liquid phase synthesis, solid phase combination, original non-classical solid phase synthesis technology, especially for the synthesis of medium-length peptides, long peptides and difficult peptide sequences。With the strong small molecule synthesis ability and advantages of Jiuzhou Pharmaceutical, we can solve many special starting material customization problems and ensure the delivery of finished products on time with quality and quantity。The polypeptide platform has the technical capabilities of main chain modification (partial special amino acids, all special amino acids, etc.), multiple cyclization (thioether bond, multi-pair disulphide bond, amide bond, etc.), amidation, side chain modification (fatty acid, PEG, etc.), methylation, fluorescent labeling, etc。With high quality product development and GMP production capacity。

Application of polypeptide technology platform

●  The synthesis of 78 protein fragments with the longest peptide sequence was solved by solid-liquid binding method。

●  The problem of directional cyclization of three pairs of disulfide bonds in 40 amino acid polypeptide fragments was solved by means of directed synthesis。

●  Through the click chemistry method, addition reaction and other reactions, the problem of directional modification or labeling of total naked peptide fragments has been solved, such as the drug development of some customer products ADC and PDC。

●  Through the non-classical solid phase synthesis technology independently developed by the platform, the problem of multi-feed solid phase resin and low atomic utilization rate has been solved, and it has been applied in thymus pentapeptide, etibaptide and other projects, reducing the cost of synthetic materials。

Platform instrument