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Solubilization technology for insoluble drugs

Insoluble Drug Solubilization Technology

At present, the main methods for solubilizing insoluble drugs include micro-powder/co-grinding technology, solid dispersion technology (spray drying/hot melt extrusion), nanocrystalline technology, cyclodextrin inclusion technology, nanoparticle/liposome/microemulsion technology, application of solubilizing/potential solvent, synthesis of water-soluble precursors and so on。The company has established mature hot melt extrusion, spray drying and other drug solubilization technologies, and successfully delivered related projects。

Application of solubilization technology for insoluble drugs

●  Hot melt extrusion: Hot melt extrusion technology (HME) is suitable for thermostable drugs and is often used to prepare amorphous solid dispersions to improve the bioavailability of insoluble drugs。 Low cost, strong continuous operation，It can be used for drugs with low solvent solubility and poor solvent stability，Hot melt extrusion technology is suitable for a variety of dosage forms，It has the functions of solution-increasing, slow release and flavor masking，Compared with the current conventional preparation technology，Easier transition from lab to production，Free from organic solvents and batch constraints，It is a more advanced and potential preparation technology。 Representative products: Posaconazole enteric-coated tablets, Ritonavir tablets, Suvoresan tablets, etc。

●  Spray drying: Spray drying is a process in which the raw material and carrier solution are sprayed into a chamber controlled by temperature, humidity and fluid conditions in the form of fine droplets for volatilization and drying to form a solid dispersion，Spray drying process can significantly improve the dissolution rate of insoluble drugs，Suitable for heat-unstable drugs，Improves bioavailability in vivo。 Representative drugs: Apatamide tablets, telmisartan tablets。